Flat brain syndrome


Lissencephaly “Flat-brain syndrome” is a set of rare brain disorders where the whole or parts of the surface of the brain appear smooth. It is a rare, gene-linked malformation that is characterized by the absence of normal convolutions (folds) in the cerebral cortex and an abnormally small head (microcephaly). In fact, it is caused by defective neural migration during embryonic development. Furthermore, symptoms include unusual facial appearance, difficulty swallowing, spasms, seizures and severe psycho-motor retardation. These vary with the severity of the brain malformation and seizure control.

First-Step experts team have been treating children with Flat brain syndrome.  Below you can read the experience of Mila and her family with the therapeutic process.


Mila was born with the rare ‘Flat Brain’ syndrome. At age two and a half, she had an extensive developmental delay. She did not talk. She just emitted monotonous sounds and expressed herself in basic ways, like laughter and crying. Moreover, she was sensitive to contact, voices, and odors, was artificially fed through a PEG tube. For the most of the day she would sit without moving. Her family and Mila started an intensive therapy process with First-Step team of experts. Finally, after the first two weeks of therapy, Mila started crawling on her belly. Today, Mila walks with support and she communicated better with her environment.

The therapy process from Mila’s parents’ perspective:

“It was and still is a fundamental experience for Mila’s development. Two years ago Mila did not move from a sitting position, now she walks with the support of a hand. It was a difficult and long journey, which is not yet completed. The First Step method has led us and allowed us to get where we are now”. – Anna Sarnelli and Dario Bonetti, Mila’s parents

Does your child have flat brain syndrome ? Contact us for learning more about the therapy process. We are happy to share with us our therapy experience with First-Step and answer your questions.